Spermidine is also related to improving the reproductive fertility of both sexes. As the global population grows, the cost of living rises and the pressures of professional life, many people decide to delay childbearing. If they do choose to become parents, they may encounter some unexpected problems along the way. Menopause, when a woman loses the ability to have children, can start at age 45, and the ovaries can age five times faster than any other organ in the body.
Although several reproductive AIDS are available, research has shifted to spermidine. Over time, the ovaries accumulate reactive oxygen species (ROS), a form of oxidative stress that damages eggs (oocytes) and causes cell aging, leading to menopause. ROS can cause abnormal development of female reproductive stem cells (FGSCs) in the ovaries. This prevents them from producing viable oocytes, greatly limiting fertility. One study hypothesized that spermidine reduces oxidative stress in FGSC. It was shown that in spermidine-treated FGSCS, autophagy and stem cell production were promoted, thereby reducing oxidative damage. This leads to the potential use of supplements in fertility treatment for women.
Similarly, spermidine may also have potential benefits for male fertility, although male fertility does not decline as precipitously as menopause. As the name suggests, spermidine was originally found in semen and is important in the production of sperm during sexual production. In fact, infertile men have been found to have lower spermidine levels than fertile men. A large part of sexual reproduction is controlled by hormones. One study examined the effects of supplements on different hormone levels in men. It found that taking supplements for 30 days significantly reduced levels of the stress hormone cortisol, which can seriously impair fertility as a survival mechanism. It also lowers levels of estradiol, an estrogen associated with reduced sexual function in men. However, levels of testosterone and the sex steroid hormone DHEAS increased, indicating improved sexual function.
Spermidine may also be effective in reducing more physical aspects of aging. One of the earliest signs of aging can be found on our faces; Fine lines, deep wrinkles and sagging skin seem to be an inevitable part of the ageing process, and a widespread fear of looking older has fuelled the skincare and anti-ageing industries. Supplements such as Primeadine, from Oxford Healthspan, promise to tackle these skin problems.
